Two people were extricated from their vehicles and one man was airlifted to a South Bend, Ind., hospital after a four-car accident Wednesday morning on U.S. Highway 12 east of Edwardsburg.

Robert Rudolph, of South Bend, was transported by MedFlight to South Bend Memorial after he sustained arm and leg injuries in the crash.

Another driver, Gurnak Singh, of Greenwood, Ind., was taken by ambulance to South Bend Memorial for rib injuries. Both had to be extricated from their vehicles.

The crash occurred at approximately 10:12 a.m. on U.S. 12 about a quarter-mile west of Garver Lake Road, according to Edwardsburg-Ontwa Police Chief Kenneth Wray.

Rudolph was traveling west on U.S. 12 when, for unknown reasons, his Chevrolet van crossed the centerline and struck an eastbound semi-truck driven by Singh nearly head-on. After the collision, Rudolph’s van glanced back into the westbound lane before traveling back into the eastbound lane and sideswiping another semi-truck driven by Edward Klein, of Mendon. The van then came to a rest on the south side of U.S. 12 facing west.

Singh’s semi went off the road and struck a large tree, Wray said.

A tire from Rudolph’s van became dislodged after the first collision and struck a car that was traveling west on U.S. 12 behind Rudolph. Edwardsburg’s Larry and Phillis Banghart were in the car hit by the tire.

Klein and the Bangharts were not injured in the accident.

A portion of U.S. 12 near the accident was closed until around 1:15 p.m.

Wray said alcohol does not appear to be a factor in the crash, which remains under investigation.