Sunday’s contest that pits the No. 3 Notre Dame Fighting Irish (24-4) against the No. 25 Louisville Cardinals (20-8) at Purcell Pavilion has a good chance to be a lopsided matchup based on our computer prediction, which projects a final score of 80-65 in favor of Notre Dame, who is big favorites by our model. Game time is at 12 p.m. ET on March 2.

According to our computer prediction, Louisville is projected to cover the spread (17.5) against Notre Dame. The two teams are expected to go under the 148.5 total.

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Notre Dame vs. Louisville Game Info & Odds

• Date: Sunday, March 2, 2025
• Time: 12 p.m. ET
• TV channel: ESPN
• Live stream: Watch this game on Fubo (Regional restrictions may apply)
• Where: South Bend, Indiana
• Venue: Purcell Pavilion
• Line: Notre Dame -17.5
• Point total: 148.5

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Notre Dame vs. Louisville Score Prediction

• Prediction:
  Notre Dame 80, Louisville 65

Spread & Total Prediction for Notre Dame vs. Louisville

• Pick ATS: Louisville (+17.5)
• Pick OU: Under (148.5)

Notre Dame’s record against the spread this season is 15-12-0, while Louisville’s is 11-9-0. In terms of hitting the over, games involving the Fighting Irish are 15-12-0 and the Cardinals are 9-11-0. The two teams score an average of 160.2 points per game, 11.7 more points than this matchup’s total. Over the past 10 games, Notre Dame has a 5-5 record against the spread while going 8-2 overall. Louisville has gone 6-4 against the spread and 7-3 overall in its last 10 matches.

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Notre Dame Performance Insights

• The Fighting Irish average 86.6 points per game (fourth in college basketball) while allowing 62.2 per outing (121st in college basketball). They have a +683 scoring differential overall and outscore opponents by 24.4 points per game.
• Notre Dame wins the rebound battle by an average of 10.7 boards. It is pulling down 40.5 rebounds per game (fourth in college basketball) compared to its opponents’ 29.8 per contest.
• Notre Dame connects on 7.8 three-pointers per game (51st in college basketball), 2.6 more than its opponents (5.2).
• The Fighting Irish rank 10th in college basketball with 97.9 points scored per 100 possessions, and 15th in college basketball defensively with 70.3 points conceded per 100 possessions.
• Notre Dame has committed 2.6 fewer turnovers per game than its opponents, averaging 15 (166th in college basketball play) while forcing 17.6 (64th in college basketball).

Louisville Performance Insights

• The Cardinals outscore opponents by 6.3 points per game (posting 73.6 points per game, 59th in college basketball, and allowing 67.3 per outing, 242nd in college basketball) and have a +176 scoring differential.
• Louisville records 33.2 rebounds per game (124th in college basketball) while allowing 30 per outing to opponents. It outrebounds opponents by 3.2 boards per game.
• Louisville hits 6.2 three-pointers per game (169th in college basketball), while its opponents have made 5.8 on average.
• Louisville wins the turnover battle by 3.5 per game, committing 15.1 (171st in college basketball) while its opponents average 18.6.

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